Design od Experiments Documents Corner


	Articoli, Search e Links Utili Di seguito vengono elencati una serie di articoli di interesse applicativo. Sebbene alcuni di essi facciano riferimento a Design-Expert © , il contenuto informativo è però nella maggior parte dei casi indipendente dal software utilizzato. L'icona segnala la disponibilità come documento PDF. Negli altri casi si accederà alla relativa pagina HTML. Qualora desideriate la traduzione di uno specifico articolo, inviate una email con la relativa richiesta. Verificheremo la possibilità di tradurlo in base alle richieste pervenute. Hypersonic Laminar-Turbulent Transition Experiment Design: From wind tunnel model definition to MDOE Approach. .A.Marino, R. Fauci, R.Donelli and A.Schettino CIRA (Italian Aerospace Research Centre), Capua, Italy "Il successo della nostra attività sta anche nella qualità dei lavori realizzati da chi ha partecipato ai nostri corsi." Streamwise porosity distribution optimization for minimising wall interference in a transonic wind tunnel. A.Marino , B. Imperatore and A.Ragni - CIRA – Italian Aerospace Research Center 2009 "Siamo veramente lieti di ospitare su questo sito una pubblicazione internazionale realizzata da un nostro cliente che utilizza i moderni concetti del Disegno degli Esperimenti e lo strumento adeguato allo scopo." Design of Experiments Helps Optimize Pharmaceutical Coating Process Upsher-Smith Laboratories used Design of Experiments to optimize a fluid bed coating process that was producing inconsistent results. Wyeth Increases Yield 11.6% in Chiral Separation with Response Surface Methods Using Response Surface Methods (RSM) Wyeth Pharmaceuticals identified a combination of factor values that increased biopharmaceutical yield 11.6% and made the process much more robust. Response Surface Methods (RSM) Achieve Design for Six Sigma (DFSS) Goals for Medical Device Manufacturing Engineers at a major medical device manufacturer used RSM to successfully model a key process for their flagship product. The RSM model then became the foundation for development of robust specifications to ensure quality at six sigma levels. Design of Experiments Helps Reduce Time to Remove Aerospace Coatings (See page 21) Aerochem Inc. used DOE to develop a chemical paint remover that would remove the coating in less than 2 hours. Aerospace Engineering & Manufacturing, June 2008 Army Case Study: Benet Uses DOE to Reduce Time Required to Optimize Complex Design Design of experiments was used for a series of computer simulations to design a new generation of muzzle brakes. DOE saves time by reducing the amount of simulations required and makes it possible to optimize. Military Embedded Systems, June 2008 Mixture Design of Experiments (DOE) for Optimal Plasma Etch This article demonstrates how to uncover "sweet spots" where multiple fab-process specifications can be met in a most desirable way. Tabletop Hockey Meets Goals for Teaching Experimental Design In this mini-paper, Mark Anderson details an in-class experiment illustrating the power of two-level factorial design. Also learn how to shoot a wicked slap shot!" Statistics Division Newsletter, (Volume 26, No. 3, Spring 2008) (hockey.pdf--Original manuscript, 365KB) Statistical Design of Experiments on Fabrication of Starch Nanoparticles—A Case Study for Application of Response Surface Methods This paper use the fabrication of nanoparticles as an example for showing a statistically-rigorous approach to design and analysis of pharmaceutical experiments. April 2008 Pharmaceutical Manufacturer Increases Yield with Response Surface Methods MannKind Corporation used designed experiments to identify and optimize critical process variables involved in producing a small molecule substrate for use in pulmonary drug delivery. Pharmaceutical Processing, April/May 2008 Designed Experiment Optimizes Method for Removing Endocrine Disrupters Researchers successfully used DOE to evaluate potential methods for removing three common endocrine disrupters. Environmental Science & Engineering, March 2008 Also published in Laboratory Equipment magazine, June 2008 Design of Experiments Helps Reduce Welding Defects from 24 to 0 per Month A major Tier 1 automotive supplier wanted to improve the already high level of quality in their manufacturing process welding nuts to a metal seat frame. They contacted Middle Tennessee State University (MTSU) and requested a design of experiments (DOE) study to determine root causes of torque failures and areas of improvement. March 2008 Implementation of High Throughput Systems for Media and Process Development In this poster, Invitrogen discusses their strategy to fully optimize robust cell culture systems using design of experiment (DOE) statistical tools in high throughput (HTP) bioassays. February 2008 Response Surface Methods (RSM) for Peak Process Performance at the Most Robust Operating Conditions This article starts with the basics on RSM before introducing two enhancements that focus on robust operating conditions: Modeling the process variance as a function of the input factors and Propagation of error(POE) transmitted from input factor variation. It discusses how to find the find the flats—high plateaus for maximum yield and broad valleys that minimize defects. Proceeding from International SEMATECH Manufacturing Initiative (ISMI) Symposium on Manufacturing Effectiveness. October 2007 Design-Expert® 7.1 software review Felix Grant of Scientific Computing World finds that Design Expert 7.1.3 builds on the many improvements from earlier upgrades. Scientific-Computing.com, November 2007 Applicazione di specifiche tecniche DoE per la progettazione di una macchina per il confezionamento di filtri per sigarette. [DoE technique application for a filter cigarette packaging machine design ] - Ivan Eusepi, Marco Righetti - G. D spa, 2007 " Una applicazione DFSS, basato sul DoE implementato nel modo compiuto e corretto, e soprattutto una chiara visione di quali vantaggi economici e culturali , queste tecniche possano portare in Azienda (Franco Anzani) " Design Challenge This case study details how the Intertape Polymer Group (IPG) used Design of Experiments (DOE) is used to solve an adhesive tape production problem. Adhesives & Sealants Industry, September, 2007 Response Surface Methods for Peak Performance This is the third article of a series on design of experiments (DOE). The first publication provided tools for process breakthroughs via two-level factorial designs. The second article illustrated how to re-formulate rubbers or plastics using powerful statistical methods for mixture design and analysis. The author now brings the focus back to process improvement and shows how to hit the sweet spot of high yield at lowest possible cost. Rubber and Plastics News, Technical Notebook, August 20, 2007 Space Shuttle Debris Impact Tool Assessment Using the Modern Design of Experiments This article describes a methodological study focused on evaluating the application of MDOE to future operational codes in a rapid and low-cost way to assess the effects of cavity geometry uncertainty. DeLoach, R., Rayos, E. M., Campbell, C. H., Rickman, S. L.; and Larsen, C. E.: "Space Shuttle Debris Impact Tool Assessment Using the Modern Design of Experiments". 45th AIAA Aerospace Sciences Meeting and Exhibit, Reno, NV Jan 8-11, 2007. Rethink Experiment Design This article details the advantages of design of experiments (DOE) over the OFAT (changing only one factor at a time) approach to experimentation. By varying factors at two levels each, but simultaneously rather than one at a time, experimenters can uncover important interactions. Chemicalprocessing.com. November 2006. Interpreting Power in Mixture DOE -- Simplified This mini-paper by Pat Whitcomb answers the question, "I evaluated my planned mixture experiment and found that it had very low power. Could you tell me what is wrong with the design?" ASQ Statistics Division Newsletter, Vol. 25, No. 1, pp. 5-8. Fall 2006. Optimisation of EDM Fast Hole Drilling through an Evaluation of Electrode Geometry In the application of EDM fast hole drilling, response surface design was used to optimize both drilling and electrode wear. Automated Enzyme Assay Design and Optimization This poster presents the use of design of experiments (DOE) and Design-Expert® software to optimize enzymatic assays. Presented at the SBS Conference. September 2006. DOE for Coatings This article is a basic introduction to design of experiments (DOE) for coatings formulations and processes. A slightly different version was published in the Coatings Technology Handbook, 3rd Edition by CRC Press in 2005. n this article Felix Grant reviews Design-Expert 7 software and compares it to other statistical software packages. Scientific Computing World. February/March 2006 Planning for the unexpected (Review) In this article Felix Grant reviews Design-Expert 7 software and compares it to other statistical software packages. Scientific Computing World. February/March 2006 A Sticky Optimization This paper demonstrates a statistical methodology that builds on subject-matter knowledge to objectively fine-tune both processes and product formulations. The concept is illustrated with an adhesives case study. (stickyoptimization.pdf--97KB) Using Design of Experiments to Assess Escherichia Coli Fermentation Robustness A statistical study was conducted to assess fermentation process robustness in the manufacture of an active pharmaceutical ingredient. DOE was used to establish critical parameters and their acceptable ranges. BioProcess International. October 2005 Trimming the FAT out of Experimental Methods A primer on DOE versus the traditional OFAT method of experimentation. A slightly different version on this article was run in OE (Optical Engineering) magazine. June/July 2005 > PCR Process Optimized via Split-Plot DOE This paper illustrates the use of design of experiments (DOE) and split-plot design to quickly and effectively determine the factor settings that maximize amplification in a polymerase chain reaction (PCR) experiment. As presented at the 2005 ASQ World Congress. May 2005 Reducing 300mm Wafer Coating Defects without Compromising Uniformity Recently, using DOE techniques, applications engineers in Rolla, Missouri were able to reduce bottom anti-reflective coating (BARC) defects on 300mm wafers and implement a new process. An edited version of this article was run in Semiconductor Manufacturing Magazine, May 2005. How Experimental Design Optimizes Assay Automation An innovative blend of hardware, software and the right training in statistical know-how supercharges research automation. This article was published online by Quality Digest. April 2005. Click here for an unedited version of the article originally published in ADVANCE for Medical Laboratory Professionals. June 28, 2004 Design of Experiments” Training Banishes Purple-Paper Blues A paper mill uses DOE to pre-define the appearance and shade of paper before full production. Published in Solutions!, Online Exclusives, Vol. 88(4), April 2005. Also appeared in "Ahead of the Curve," a weekly newsletter published by TAPPI. Progettazione di Miscele per la produzione di vernici Nell'ambito della razionalizzazione e del potenziamento dell'attività di sviluppo di processo e di prodotto, è stato avviato un progetto allo scopo di verificare l'applicabilità nel settore della formulazione di pitture e vernici ad uso conciario del MANUALE UNICHIM N.180 (pubblicato su RICH MAC Chimica News - Jun 05) Creating Superior Electroluminescent Backlighting with Mixture Design Engineers use mixture design to create thinner, whiter keypad backlighting. A slightly different version was published in Product Design & Development, February 2005. Low-Viscosity Phthalates for Flexible Packaging Polyurethane Adhesives DOE is used in this study demonstrating the versatile compatibility of a unique polyester polyol, PD-90 LV, with both polyester and polyether polyols. Adhesives & Sealants Industry. February 2005 Improving Solder-Paste Processes Through Experimentation Proper application of solder paste onto a PCb is essential in surface mount assemblies. In this case study DOE was used to understand this process, and ultimately to improve electrical yields. Surface Mount Technology (SMT), December 2004 Response Surface Methods for Process Optimization This article explores how optimal experimental design can map performance in the presence of multifactor linear constraints. Desktop Engineering. Solving Process Issues at an ASIC Fab using Design of Experiments Engineers solved two perplexing wafer production mysteries using design of experiments (DOE), saving the company $180,000 a year. MICRO Magazine. July 2004 Interpreting Power in Mixture DOE Simplified Adapted by Mark Anderson from a detailed manuscript by Pat Whitcomb. July 2004 Screening dei parametri di processo in presenza di interazioni Questo articolo introduce un nuovo e più efficiente tipo di disegno fractional two-level factorial per lo screening dei fattori di un processo. Screening Process Factors In The Presence of Interactions This article introduces a new, more efficient type of fractional two-level factorial design of experiments (DOE) tailored for the screening of process factors. These designs are referred to as “Min Res IV.” Presented at AQC 2004 Toronto. May 2004 Tabor Test or Oscillating Sand? DOE Improves Polycarbonate Plasma Coating Process Researchers at Exatec, LLC, determined that the oscillating sand test reveals better wear assessment information for polycarbonates. This finding has allowed the company to optimize coating processes. Paint & Coatings Industry (PCI). March 2004 (Inserire Stat-Ease nella Search box per trovare l'articolo.) Formulating by Design To simplify formulation tasks when searching for hot-melt solutions, Stepan Co. developed a design of experiments (DOE) ‘mapping' approach to their new ortho-phlathic-based polyol products. They wanted to discover how the products work within their specific applications. Adhesives & Sealants Industry (ASI). March 2004 (Inserire Stat-Ease nella Search box per trovare l'articolo.) That Voodoo We Do—Marketers Are Embracing Statistical Design of Experiments When properly applied to marketing, Design of Experiments (DOE) is a marketer's silver bullet . March 2004 Optimizing Formulas by Experimental Design Changing and then re-testing just one parameter at a time still seems to be the norm for the formulation chemist, but it is not the most productive approach. In fact, this “shotgun” approach increases the probability of missing the best possible finished product. A more reliable and expedient method of optimizing a formulation is by design of experiments (DOE). The NY Chapter Society of Cosmetic Chemists' newsletter "Cosmetiscope". March 2004 Unearthing Optimum Soil Treatments Weak subgrade soils are often chemically treated, or modified, to add strength and stability to support the heavy construction vehicles required for building highways. DOE was used to develop a treatment that enabled contractors to quickly establish stable subgrades. Hard Hat News. January 2004 An Efficient Approach to Cell Culture Medium Optimization—A Statistical Method to Medium Mixing Sigma-Aldrich Biotechnology used DOE to increase cell growth and productivity for a particular recombinant CHO clone. Reprinted with the permission of Sigma-Aldrich Corporation. January 2004 Company Seeks New Customers: Engineers as Credible Marketers Trade publication articles written by engineers are a great marketing tool, but engineers are often not polished writers. The solution—work with specialty writers. The Business to Business Marketer. January 2004 Come diagnosticare e gestire dati sperimentali scadenti Questo articolo è relativo ad uno degli argomenti più spinosi per ogni sperimentatore si trova ad affrontare: come trattare risultati individuali che non sembrano adattarsi con il resto dei dati. L’ obiettivo è quello di fornire una serie di strumenti grafici per diagnosticare in modo semplice i dati anomali e verificare l’ esigenza di una eventuale trasformazione. Automazione e Strumentazione - May 05 How to Use Graphs to Diagnose and Deal with Bad Experimental Data This article deals with thorny issues that confront every experimenter – how to handle individual results that do not appear to fit with the rest of the data. November 2003 Augmented Ruggedness Testing to Prevent Failures Failures in the processing and use of products can often be prevented by applying a form of DOE called ruggedness testing. Check out this article to see how it's done. Quality Progress May 2003 DOE Software Paints Picture of Powder Coating Defects How do you react when a defect arises within one of your top powder coating products that defies conventional problem-solving techniques? You look for answers with DOE. Powder Coating April 2003 The Influence of Physico-Chemical and Process Conditions on the Physical Stability of Plasmid DNA Complexes using Response Surface Methodology This paper introduces a new method of assessing the engineering effects of process and material factors on the colloidal properties of plasmid-DNA delivery systems based on response surface methodology (RSM) and experimental techniques. Biotechnol. Appl. Biochem. (2003) 37, (225-234) April 2003 Using Design of Experiments to Make Processes More Robust to Environmental and Input Variations This article explains why standard factorial designs (one array) offer a cost-effective alternative to parameter designs (two array) made popular by Taguchi. It then discusses advanced tools for robust design that involve application of response surface methods (RSM) and measurement of propagation of error (POE). Paint and Coatings Industry (PCI) February 2003 The Six Sigma Method and Design of Experiments This article by Peter Peterka (http://www.6sigma.us/) explains what Six Sigma is and DOE's role in it. The DOE FAQ Alert. December 2002 Mixture DOE Uncovers Formulations Quicker This article offers a simple case study that illustrates how to put rubber or plastics formulations to the test by using powerful statistical methods for mixture design and analysis. Rubber & Plastics News. October 2002 Small, Efficient, Equireplicated Resolution V Fractions of 2^k designs and their Application to Central Composite Designs Gary W. Oehlert & Pat Whitcomb present a class of equireplicated, irregular fractions of two-series designs constructed algorithmically using the D-optimality criterion. Presented at the Fall Technical Conference 2002. October 2002 Design-Expert DOES it better (Review) Anny Dentener (http://www.foodinc.co.nz/) reviews Design-Expert 6 for the food industry. Food Technology in New Zealand (http://www.foodtechnology.co.nz/). September 2002 Design, Analyze, and Optimize with Design-Expert (Review) Katherine T. Alben from the New York State Department of Health reviews Design-Expert 6 software for use in experimental chemistry. Analytical Chemistry. April 2002 Technology Flexes its Muscles Design of experiments (DOE) was used to examine the effects of adhesive components in electron beam (EB) curable laminating adhesives for flexible packaging. Adhesives Age. March 2002 Cost- Effective and Information-Efficient Robust Design for Optimizing Processes and Accomplishing Six Sigma Objectives Standard factorial designs (one array) offer a cost-effective and information-efficient robust design alternative to parameter designs (two -array) made popular by Taguchi. This paper compares these two methods (one-array versus two-array) in depth via an industrial case study. It then discusses advanced tools for robust design that involve application of response surface methods (RSM) and measurement of propagation of error (POE). Vedere anche questo articolo Knead for Speed Case study from Today's Chemist at Work magazine. February 2002 Achieving Six Sigma Objectives for Variability Reduction in Coating Formulation and Processing Cover story from Paint & Coatings Industry. November 2001 Enhancing Solid-Phase Disk Extraction Performance with Design of Experiments Case study on 3M Empore extraction disks. American Laboratory (click here for the magazine article link). November 2001 Sizing Fixed Effects for Computing Power in Experimental Designs Power tells us the probability of rejecting the null hypothesis for an effect of a given size and helps us select an appropriate design prior to running the experiment. This paper describes a general approach for sizing effects that covers a wide variety of designs. Quality and Reliability Engineering International. July 27, 2001 The Next Generation in Weatherable Hardcoats for Polycarbonate This paper received the Best Paper Award at the International Coatings for Plastics Symposium, June 4–6, 2001, in Troy, MI. Paint & Coatings Industry. June 2001 Engineering Software Quickens Product Launch Mary Kay case study from Packaging World magazine. January 2001 Eliminate Nuisance Variability with a Latin Square Design Case study from Douglas Montgomery's, "Design & Analysis of Experiments", 5th Edition Screening Ingredients Most Efficiently with Two-Level Design of Experiments (DOE) A DOE on machine-made bread shows how clever application of statistical methods quickly screens alternative ingredients to see which, if any, impair the desired reaction. DOE combinato: Miscele e Processi Esempio applicativo di metodologie statistiche per l’ ottimizzazione di una formulazione, con simultanea ottimizzazione dei parametri di processo che forniscono la massima risposta. Designing Experiments that Combine Mixture Components with Process Factors A version of this article appeared in PCI Magazine. November 2000 A More User-Friendly Design-Expert - Design-Expert Release 6.01(Review) Software review in Quality Digest magazine. October 2000 Pilot-to-Production Requires Design of Experiments to Unclog Herbicide Case study on how Aventis CropScience used DOE for Herbicide development. Using Simulation Software for Design of Experiment Training This article shows how Hot Rod Burnout—Championship Drag Racing® simulation software is used to make learning DOE fun. DOE It Yourself Fun science projects* compiled by Mark J. Anderson, Principal, Stat-Ease, Inc. Tabletop Hockey Meets Goals for Teaching Experimental Design Instructions for one of the DOE It Yourself projects mentioned above. 1997 Energy Project Relies on DOE Article originally in Quality magazine. A slightly different version appears here. October 2000 Design of Experiments Software Helps Clear Wafer Transport Traffic Jams Article in Micro magazine. July/August 2000 Design of Experiments Increase Hot-Ink Roller Impressions (and Perceptions) by Jennifer Borkovich. Published in the May 2000 issue of American Ink Maker and in a web exclusive for PCI Magazine. April 2000 Save Runs, Yet Reveal Breakthrough Interactions by Doing Only a Semifoldover on Medium-Resolution Screening Designs Via case studies, this paper reviews the strategy of foldover on low-resolution (III) two-level fractional factorials and demonstrates how to reduce experimental runs by making use of semifoldover methods to augment medium-resolution (IV) designs. Computer-Aided Tools for Optimal Mixture Design Article in Paint and Coatings Industry. November 1999 Computer-Aided Tools for Optimal Mixture Design A somewhat different version of the article above. Solving Core Shear with Design of Experiments Article originally in Job Shop Technology. A slightly different version appears here. March 1999 Soluzioni per un DOE corretto Questo articolo identifica otto soluzioni per avere successo nell’applicazione degli strumenti statistici del Design of Experiments. Automazione e Strumentazione - Jun 04 Keys to Successful Designed Experiments This article was presented at the Quality Management Division of American Society for Quality conference. January 20, 1999 Design of Experiments for Ruggedness Testing: Case Study on Paraffin Therapy Bath A version of this article appeared in Medical Device & Diagnostic Industry. January 1999 Understanding Your Process (Review) Review of Design-Expert software in Desktop Engineering. June 1998 The importance of hierarchy in design of experiments (DOE) Article from Quality in Manufacturing magazine. March/April 1998 La ricerca della formulazione ottimale per le miscele La tecnica del DOE (Design of Experiments) fornisce un metodo efficiente per ottimizzare i processi e può portare a risultati interessanti se applicata alle formulazioni. Come accelerare l’esplorazione delle possibili alternative compositive di una miscela. RICH MAC Chimica News - May 04 Find the Optimal Formulation with Mixtures A version of this article appeared in Chemical Engineering Progress. April 1998 DOE in Non-Manufacturing Processes Esempi di utilizzo delle tecniche del DOE per applicazioni cosiddette Transazionali (Six Sigma in Non-Manufacturing Environment) Achieving Breakthroughs in Non-Manufacturing Processes via Design of Experiments (DOE) Inspirational examples* compiled by Mark J. Anderson, Principal, Stat-Ease, Inc. 1998 (revised 2004) Mixing it up with Computer-Aided Design A somewhat different version of this article appeared in Today's Chemist at Work. November 1997 Computer-Aided Design of Experiments for Formulations A somewhat different version of this article appeared in Modern Paint and Coatings. June 1997 Make Breakthrough Improvements with Experiment Design A somewhat different version of this article appeared in Rubber & Plastics News. June 1997 Software Sleuth Solves Engineering Problems A somewhat different version of this article appeared in Machine Design. June 5, 1997 Optimize Your Process-Optimization Efforts A somewhat different version of this article appeared in Chemical Engineering Progress. December 1996 A Balancing Act: Optimizing a Product's Properties Quality Progress. ©2002 American Society for Quality. Reprinted with permission. June 1999 Applying DOE to Microwave Popcorn Process Industries (PI) Quality. July/August 1993 (revised 2/98) Use of Replication in Almost Unreplicated Factorial This paper discusses supplementing Lenth's method by combining his estimate of error variance from small factorial effects with the pure error variance from replicate observations or (possibly) other estimates of error variance. The Role of Pure Error on Normal Probability Plots A look at augmenting the usual probability plot effects with points representing pure error. Six Sigma Program Success Factors Da leggere attentamente prima di investire un solo euro in una iniziativa Six-Sigma. more Search ... @Engineering Statistic HandBook